Karolinska Institutet

Karolinska Institutet (KI) is the largest centre for medical education and research in Sweden and home of the Nobel Prize in Physiology or Medicine. KI has about 4700 employees, 2000 active graduate students and 5800 students. The university also houses a large number of guest researchers and international scholars. KI ranks 44th in the Times Higher Education ranking 2015.

The IMM Institute of Environmental Medicine (Institutet för Miljömedicin in Swedish), a department at KI, is devoted to physical and chemical aspects of environmental medicine and health protection. The Department has about 350 employees engaged in research, risk assessment and education within four major areas; Epidemiology, Occupational & Environmental Medicine, Physiology and Toxicology. IMM provides regulatory authorities in Sweden and EC as well as international organizations like The World Health Organization (WHO) with expertise, support and advice regarding environmental health risk assessments and trains toxicologists and global health professionals.

KI will provide expertise and knowledge on advanced computational analysis tools for integrating high- throughput screening (HTS) and high content analysis (HCA) data into the development of grouping approaches and the risk banding tool. The team at KI has extensive knowledge in bioinformatics, toxicogenomics, nanotoxicology and in vitro cell culturing methods, as well as large scale data management. Specifically and relevant to the current project proposal, the team at KI has experience with mathematical modelling applicable for elucidation of toxicity pathways and toxicokinetics in relation to hazard characterization paradigms.

In caLIBRAte KI will be involved in WP2 and WP5:

  •  In WP2 KI will lead Task 2.4 where the added value of innovative hazard/exposure characterization

    methods/models will be developed. Task 2.5 involves further refinement of the developed hazard/exposure

    models for full applicability in the stage-gate model.

  •  WP5 incorporates data and ontology frameworks developed within other EU nano-projects, such as

    eNanoMapper, NanoREG I & II and NanoSolutions (through the caLIBRAte partner MISVIK Biology). Involving deep interaction with MISVIK Biology data gaps will be filled and 10 new complete data sets will be generated for testing and calibrating in WP7